Mastering the Quantitative Bioanalysis of Large Peptides and Proteins:

A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma.

As peptide drugs, such as GLP-1 receptor agonist Semaglutide become central in treatment of a range of therapeutic areas, reliable bioanalysis methods, supporting DMPK evaluations and onwards transition through clinical trials, are essential to their successful progression to market. Development of accurate and robust analytical quantitative methodologies for peptides brings inherent challenges in efficient mrm optimisation, non specific binding and assay sensitivity. This exclusive webinar will dive into the latest advancements in comprehensive LC‑MS/MS analytical workflows, resolving these challenges, and enabling efficient development of robust, sensitive large peptide LC‑MS/MS assays.

Join us as Samantha Ferries, Senior Applications Chemist at Waters Corporation, presents efficiency and performance benefit insights from her recent work in optimizing the LC-MS/MS quantification of Semaglutide in plasma.

Key Takeaways:

§  Learn step-by-step how to streamline bioanalysis workflows for large peptides such as Semaglutide.

§  Discover practical solutions to common obstacles like non-specific binding and efficient mrm optimisation.

§  Gain insights into boosting sensitivity without compromising the reliability of your bioanalytical methods.

Samantha Ferries received her PhD in proteomics from the University of Liverpool in 2018. Since joining Waters she has worked on a variety of application areas including Biomedical Research, Pharmaceuticals and Food & Environmental, with a focus on LCMS/MS method development. In 2021 Samantha was part of the team that worked to develop the SARS-CoV-2 LCMS Kit (RUO) to detect & quantify SARS-CoV-2 signature NCAP peptides.

Missed one of our previous episodes?

Episode 1: More from less: LC-MS/MS an Enabling Technology to Maximise Bioanalytical Data Collection from Small Sample Volumes

Episode 2: Elevating Oligonucleotide Bioanalysis: LOQ, Dynamic Range, and Innovative Sample Preparation Techniques

Watch them now on-demand →

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