Focus on LC-MS solutions for Clinical Research - May 25-29

Liquid chromatography-mass spectrometry (LC-MS) has become a well-established
tool for the identification and quantification of small molecules in research settings,
and has transitioned to a higher-throughput, safer, and lower-cost alternative to
immunoassays for routine testing – enabling smaller labs to adopt the technology
with ease. Thanks to LC-MS sensitivity and specificity, small molecule analysis can
now be performed on a variety of sample types in a clinical research setting—including
whole blood, serum, plasma, urine and cerebrospinal fluid (CSF).

During Waters Clinical Webinar Week, you will learn how LC-MS can help you in
your daily lab routine in various area of clinical diagnostics. Each day, a specific
topic will be addressed by a one-hour presentation and Q&A session.

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Clinical Webinar Week Agenda

Monday, May 25th - 2pm CET

Clinical Mass Spectrometry: Past, Present and Future
A presentation by Mike Morris, Senior Director of MS research

This presentation will focus on the use of soft ionisation techniques applied to
problems of clinical interest. The key milestones that Waters has passed in the
implementation of mass spectrometry detection into the clinical market will be
discussed, and then the early application of electrospray to the study of haemoglobin
variants through the application of tandem mass spectrometry to newborn screening
and beyond to assays that are in regular use today will be reviewed. The final part of
the presentation will look at the potential future uses of technologies in clinical
research, as well as considering some of the efforts that are currently underway in
supporting the research into Covid-19.

Key literature references will allow the viewer to study the different applications to a
greater depth.

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Tuesday, May 26th - 5pm CET

Sensitivity, Selectivity, and Speed: Solving Analytical Challenges in
Endocrinology using LC-MS/MS for Clinical Research
A presentation by Dominic Foley, Senior Scientist

The use of LC-MS/MS technologies in Endocrinology for clinical research is
experiencing rapid growth. Analytical sensitivity, selectivity and speed are all important
aspects of endocrine methodologies which can be augmented by using high sensitivity
LC-MS/MS platforms such as the Xevo TQ-S micro and Xevo TQ-XS mass
spectrometers.

During this webinar you'll learn how to understand the analytical benefits of using LC-
MS/MS for endocrine methods over other platforms, improve analytical performance by
the incorporation of selective sample preparation workflows and how offline automation
can be leveraged to improve method performance and optimize efficiency in LC-
MS/MS laboratories

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Wednesday, May 27th - 2pm CET

Spot the Difference: What Causes Variability in Flow-Injection, Dried Blood
Spot Analysis, and What You Can Do About It
A presentation by Heather Brown, Principal scientist

Tandem mass spectrometry is the detection method of choice when analytical
specificity and speed of analysis is needed. Flow-injection analysis tandem mass
spectrometry (FIA-MS/MS) enables the rapid and multiplexed screening of
compounds, in a single injection. This webinar aims to illustrate some of the factors
which can influence variability in FIA-MS/MS data, and to provide the audience with
ideas for designing system suitability testing procedures to identify sample and
instrument-issues before they impact service.

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Thursday, May 27th - 2pm CET

IVDR Implementation for Clinical Laboratories
A presentation by Marta Carnielli, PharmD, Technical Officer IVD - TÜV SÜD
Product Service GmbH

By May 2022, the in-vitro diagnostics regulation (IVDR) will replace the current in-vitro
diagnostics directive (IDD) across the EU. The regulations have a broader scope than
the previous laws and specifically include software and novel technologies such as
genetic testing. Clinical MS users are affected by delayed publication of IVDR
implementation guidelines and notified body certification.

Our free webinar will help you understand the implications of the new regulation.
Following the webinar, Ms Carnielli will be available for a Q&A.

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Friday, May 29th - 11am CET

Analysis of Methylmalonic Acid (MMA) in Serum Using the Xevo TQ-S micro
for Clinical Research
A presentation by Dominic Foley, Senior Scientist

Chromatographic separation is key in separating MMA from isobaric and isomeric
species, such as succinic acid, that can cause a significant concentration bias. To help
facilitate adoption of this methodology, a simplified workflow is necessary to enable a
high throughput of samples. Here we describe a clinical research method utilizing
Ostro phospholipid removal plate technology for the extraction of MMA from serum.

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