Waters: Genetic Medicine Update: April - RNA Edition
Genetic Medicine Insights: April - Spotlight on RNAs
From 500 to 10,000+ nucleotides. Leave no detail to chance.
Meet the Complexity of Therapeutic mRNA with Powerful Tools and Workflows for Confident Attribute Understanding
Discover innovative RNA workflows supported by the latest version of the waters_connect Software suite of applications for nucleic acid LC-MS analysis.
In this application note, analytical scientists working with an mRNA molecule detail how they can accelerate sequence confirmation and quality attribute analysis using the enhanced LC-MS workflows supported by the latest suite of nucleic acid applications in the waters_connect ™ Platform. Learn how LC-MS complements traditional and next-gen sequencing approaches for RNA sequence map analysis— from characterization to QC— and how smarter multi-enzyme digestion strategies can simplify the task of obtaining high sequence coverage from those maps.
Navigating Regulatory Guidance for LNP and Liposomal Drug Characterization Using FFF-MALS Advancing RNA Quality with Streamlined LC–MS Workflows
Download our comprehensive application notebook detailing LC–MS strategies for RNA digestion, sequence mapping, capping analysis, and poly(A) tail characterization.
Enhance your RNA therapeutic development with this application notebook outlining end-to-end LC–MS workflows for mRNA and sgRNA characterization. Discover how tunable RapiZyme™ RNases, high-performance ACQUITY™ Premier Columns, and automated waters_connect Informatics deliver confident sequence mapping, modification profiling, and critical quality attribute (CQA) assessment. Learn approaches for analyzing 5’ cap efficiency, poly(A) tail heterogeneity, and digestion-based sequence confirmation using robust, compliance-ready methods. These integrated solutions support consistent, high-quality RNA analytics from discovery through manufacturing.
Accurately Measure LNP Encapsulation Efficiency with Automation
Critical quality testing for RNA-loaded lipid nanoparticle (LNP) therapeutics
Encapsulation efficiency determines RNA therapeutic efficacy, but manual testing introduces significant variability. Learn how automated sample prep with Andrew+™ Robot delivers reproducible LNP encapsulation measurements essential for formulation optimization and lot release. Achieve consistent separation of encapsulated and free RNA through precise sample handling. This approach is critical for mRNA vaccines, siRNA therapeutics, and gene-editing delivery, where encapsulation directly impacts potency. Meet regulatory requirements with validated, traceable encapsulation testing. Access this automated LNP quality control protocol to improve data confidence.
Comprehensive Chromatographic Assessment of Forced Degraded In Vitro Transcribed mRNA
Watch this webinar with insights from Regeneron on chromatographic strategies for assessing mRNA stability
How can we reliably assess mRNA stability during development? Jacklyn Cika from Regeneron Pharmaceuticals showcases SEC-MALS and other chromatographic methods to evaluate thermally stressed in vitro transcribed (IVT) mRNA. The study explores chromatographic workflows and stability-indicating assays for monitoring degradation, detecting impurities, and assessing CQAs, while revealing how impurities such as divalent metal ions can accelerate mRNA fragmentation during processing and storage.
Stop Losing Your Critical Biotherapeutic Peaks to Metal Adsorption
Learn how MaxPeak High Performance Surfaces (HPS) Technology eliminates non-specific adsorption to deliver the sensitivity, reproducibility, and resolution your complex biopharmaceutical separations require.
Legacy stainless-steel LC instrument and column hardware often trigger non-specific adsorption, leading to broad peaks, poor reproducibility, and inaccurate results. This hidden challenge compromises the analysis of intact proteins, peptides, and oligonucleotides. Learn how to mitigate metal-induced phenomena and achieve a new benchmark in chromatographic performance with our holistic hardware solution. Download our comprehensive eBook to learn how MaxPeak™ HPS Technology improves recovery and provides higher confidence in your most critical analytical data.
Characterizing Therapeutic RNAs with Only Sequencing Techniques is Not Getting the Job Done
Learn how LC-MS workflows can transform your approach to RNA characterization and quality analysis in this webinar
Join the on-demand version of the 2026 webinar, "Accelerating Sample to Decision: Automated LC-MS Workflows for RNA Therapeutics and Vaccines," to explore innovative LC-MS tools and workflows for RNA sequence and modification analysis. Speakers from Waters and BioSpring share best practices for achieving high-coverage RNA maps and for leveraging automated informatics for streamlined analysis. Gain insight into how LC-MS complements traditional and next-gen sequencing techniques for assessing the attributes of RNA therapeutics and vaccines.
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